Readers ask: What Is Ttp In Orthopedics?

What does TTP mean in medical terms?

Thrombotic thrombocytopenic purpura ( TTP ) is a blood disorder in which platelet clumps form in small blood vessels.

How do you treat TTP?

Treatment options for TTP refractory to PEX

• Corticosteroids. Corticosteroids are used in the acute management of acquired TTP, and should be started upfront together with PEX.
• Twice-daily PEX.
• Rituximab.
• Splenectomy.
• Cyclosporine.
• Cyclophosphamide and vincristine.
• Bortezomib.
• N-acetylcysteine.

How is TTP diagnosed?

Diagnosis. Laboratory studies for suspected TTP include a CBC, platelet count, blood smears, coagulation studies, BUN creatinine, and serum bilirubin and lactate dehydrogenase. The exact etiology of TTP is unknown. 5

How serious is TTP?

Thrombotic Thrombocytopenic Purpura is a rare blood disorder that is considered a true medical emergency. TTP is diagnosed at a rate of 3-4in 1 million people per year. Potentially fatal complications can result from internal blood clotting, with damage to critical organs such as the brain and heart.

What drugs can cause TTP?

Drugs such as mitomycin, cyclosporine, cisplatin, bleomycin, quinine, and ticlopidine have been associated with HUS and TTP.

Who gets TTP?

It usually affects people between 20 to 50 years of age but people of any age may be affected. TTP is occasionally associated with pregnancy and collagen-vascular diseases (a group of diseases affecting connective tissue).

How long can you live with TTP?

In the authors’ series of 126 patients, the estimated 10-year survival rate of patients without comorbid conditions was 82%, compared with a survival rate of 50% if comorbid conditions were present. 5

What is the cause of TTP?

Causes. A lack of activity in the ADAMTS13 enzyme (a type of protein in the blood) causes thrombotic thrombocytopenic purpura ( TTP ). The ADAMTS13 gene controls the enzyme, which is involved in blood clotting. Not having enough enzyme activity causes overactive blood clotting.

What causes acquired TTP?

Acquired TTP is caused when a person’s body mistakingly makes antibodies that block the activity of the ADAMTS13 enzyme. THe ADAMTS13 enzyme normally helps control the activity of certain blood clotting factors. Treatment includes plasma exchange and in some cases may also include corticosteroid therapy or rituximab.

What are the features of TTP?

TTP is characterized by five features (pentad) consisting of thrombocytopenia, microangiopathic hemolytic anemia (MAHA), fever, variable neurological abnormalities (mostly confusion or severe headache), and renal failure.

What is TTP pentad?

Thrombotic Thrombocytopenic Purpura ( TTP ) is a type of microangiopathic hemolytic anemia that classically has been characterized by the pentad of fever, thrombocytopenia, hemolytic anemia, renal dysfunction, and neurologic dysfunction.

Is TTP genetic?

Inherited TTP is a genetic condition where the ADAMTS13 gene is faulty and doesn’t make normally functioning ADAMTS13 enzymes. People with inherited TTP have two copies of the faulty gene, one passed down through the genes from each parent.

Can you survive TTP?

The most striking evidence for the impact of morbidities following recovery from TTP is decreased survival. Among the 77 patients who survived their initial episode of TTP (1995-2017), 16 (21%) have subsequently died, all before their expected age of death (median difference, 22 years; range 4-55 years).

Can you get TTP more than once?

Our experience is that TTP can recur during pregnancy, but this is uncommon. Most women have uncomplicated, successful pregnancies. During the past 20 years, 10 of our patients have had 17 subsequent pregnancies.

Can TTP cause strokes?

Ischaemic stroke has been reported as a consequence of TTP. However, strokes due to a large cerebral artery occlusion (LCAO) are rare in patients with TTP.